Structure-based design assumes the target holds still. For a protein that never does, a single crystal structure is not simplification — it is fiction.
$785 million for the right to decide later. The option structure is what companies do when a platform is promising and entirely preclinical.
Synlogic shareholders keep 2.3%. What is being bought is the listing, and the $278 million arriving alongside it.
The brain treats weight loss as a survival threat and pushes back with hunger, cravings and reduced energy expenditure. That is why the drugs work only while taken.
An 11.6-point drop on a 56-point anxiety scale, 5.4 points better than placebo, from a single dosing session lasting about six and a half hours. The second positive Phase 3 for the drug this year.
CPAP works when worn. A once-nightly pill combining a generic ADHD drug with a novel compound is betting that adherence is the real problem.
Founded 2024, licensed the asset from China, public by 2026 with $382 million. The speed is the story as much as the drug.
Older ankles are stiffer because opposing muscles tense against each other. That buys stability and costs the springy push-off that makes walking cheap.
In the 106-patient HOPE-3 trial, boys and young men on deramiocel lost arm and elbow function markedly slower than those on placebo, ahead of an August FDA decision.
Half a million DNA variants, measured for activity, then fed to a machine-learning model. The result: the sequence signature marking where a gene starts — found in about 60% of human genes.
RNA drugs work brilliantly in the liver because the liver takes them up by accident. Everywhere else requires an escort.
Blood bicarbonate rose about 7% across two decades of NHANES data while atmospheric CO2 went from 369 to over 420 ppm. The researchers are explicit that two trends moving together is not causation.