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Sequencing eight Myotis bat species uncovered genetic tricks linking their famous virus tolerance to cancer resistance and longevity — clues that could inform human aging research.
Studying 107 adults aged 26 to 86, researchers found that aging muscles increasingly tense against each other around the ankle — a “safety-first” stiffening that saps push-off power.
By testing half a million DNA variants, researchers pinned down the signature of the “initiator” — the element that marks where a gene is switched on — and found it in roughly 60% of human genes.
Analyzing 20 years of U.S. health data, researchers found blood bicarbonate has crept up as CO2 climbed — a correlation they say warrants monitoring, not alarm.
A study of older adults with exceptional memory finds their gift can't be explained by lucky Alzheimer's-protective genes, pointing to other factors.
Mapping genome architecture and gene activity in the same cells reveals a new layer of dysfunction in Alzheimer's — and possible therapeutic targets.
University of Illinois researchers rewrote how the huntingtin gene is read, cutting toxic protein fragments and brain damage in mice — an early, preclinical step.
Mapping brain tissue from donors aged 20 to 95, researchers saw the hippocampus’s immune cells transform in midlife — a possible link between aging and dementia.
Princeton researchers found that when fiber runs low, gut bacteria break down the intestine’s protective mucus — producing harmful byproducts linked to worse outcomes in disease.
Lab-grown human neurons show the protective APOE2 variant is better at repairing DNA damage and resisting the cellular aging linked to neurodegeneration.
University of Pennsylvania researchers found a gum made from lablab beans sharply reduced HPV in oral samples — an early, lab-only step toward preventing HPV-linked cancers.
Yale researchers found that omega-3 and omega-6 fats can dampen natural killer cells’ tumor-fighting power in mice — via a receptor called LRP5. It’s early, and not a reason to change your diet.
Whitehead Institute scientists found polyamines act as ‘storage lockers’ for iron — and draining them could poison cancer cells with their own iron.
Nagoya University researchers found it’s not the complement protein C3 in the blood that matters, but the C3 produced at the tumor — and it helps immunotherapy work.
Beyond hunger, drugs like Ozempic appear to dial down urges for alcohol, nicotine and more — and researchers point to a reward hub called the lateral septum.
A USC deep-learning model, trained on nearly 15,000 scans, shows which parts of the brain age fastest — and flags accelerated aging in areas hit early by Alzheimer’s.
Researchers used AI to redesign antibody fragments so they can work inside cells — a long-standing hurdle — and aimed them at the toxic proteins behind Alzheimer’s, Parkinson’s and motor neurone disease.
In mice, the APOE4 variant raised a protein that made neurons smaller and overexcitable long before memory faltered — and dialing that protein back reversed the damage.
Edinburgh and Bristol researchers traced disc degeneration to a collagen defect and mineral buildup — and found existing drugs could slow it, hinting at alternatives to surgery.
Kindred Companion Sciences edited a single gene to knock out Can f 1, the protein behind most dog allergies — and says two edited beagles are healthy at nearly two years old.
Vanderbilt researchers created the first compounds to selectively switch a protein family called TAOK on or off — research tools, not drugs, that could open new Alzheimer’s leads.
A Science study traced nine stages of metastasis and found a quiet, immune-evading cell state that, when disrupted, let the immune system fight the spreading cancer.
Hebrew University researchers show that the overactive gene switches driving tumor growth physically strain and snap DNA — a stress point that might be turned against cancer.
In flatworms, Stanford researchers found ‘ruptoblasts’ that self-destruct within seconds to destroy nearby bacteria — a defense mechanism never seen before.
Scientists found that triple-negative breast tumors recruit immune cells to release a protein that draws nerves inward, fueling growth. An existing drug blocked the process in mice.
A large Nature study found that inflammation — not a weakened immune system — reactivates viruses like Epstein-Barr during severe COVID, and one viral family tracked with long COVID.
In supercentenarians, a rare hybrid “killer-helper” T cell made up nearly a fifth of all T cells — hinting the immune system keeps adapting even in extreme old age.
Analyzing thousands of people, researchers found that drugs from antibiotics to antidepressants left fingerprints in the gut — some detectable years after the last dose.
Whole-genome sequencing of the parasite behind the deadliest malaria uncovered new mutations linked to reduced susceptibility to frontline artemisinin-based therapy.
An observational analysis of more than 31,000 patients tied one widely used class of blood-pressure pills to a 33% higher risk of serious kidney events — though researchers stress it cannot prove cause.
In lab-infected human immune cells, dexamethasone dialed down damaging inflammation from a stubborn lung infection while still letting the cells fight the bacteria.
Altimmune's pemvidutide reduced heavy-drinking days more than placebo in a Phase 2 study — early evidence that GLP-1-class drugs may curb more than appetite.
By re-lengthening a shortened RNA, scientists restored the molecular flag that lets immune cells see prostate tumors — turning on checkpoint therapy that usually fails.
Researchers paired live malaria parasites with a drug that stops them in the liver, converting infectious bites into immunizing events that produced durable protection in animals.
Studying human brains — including healthy centenarians — scientists found a moment when microglia switch from helpful to harmful, shaping Alzheimer's outcomes.
Male sex hormones dampened allergic lung inflammation in mice by strengthening nerve signals — a mechanism that may help explain why boys often outgrow asthma more than girls.
A Cambridge study explains an obesity-drug paradox — the GIPR receptor does opposite jobs in different brain regions, so agonists and antagonists both work.
By tracking some patients for up to 25 years, Sanger Institute researchers found DNA changes that flag which slow-growing blood cancers will progress — long before symptoms.
Stanford researchers coaxed immune cells into a tumor-infiltrating form — without genetic engineering — that penetrated cancers better and, paired with an antibody drug, sharply slowed growth in mice.
A study of a rare fat-loss disorder shows healthy fat tissue is metabolically vital — and when it becomes inflamed and disappears, diabetes can follow.