The constraint is not the molecule or the market. It is the number of people qualified to run peptide synthesis at commercial scale under pharmaceutical quality systems.
Three mutations and two deletions spreading fast in Uganda, blunting the frontline malaria combination. One gene appears to reduce response to both drugs at once — which is not how combination therapy is supposed to fail.
Venture funding up 25%, eight IPOs, record lab space — and 3,605 fewer jobs. The money came back to Massachusetts biotech; the employment did not follow it.
Another large study, another 24% lower dementia rate among the vaccinated. The authors say plainly it cannot establish cause — and explain exactly why their adjustments did not close the gap.
Tay-Sachs and Sandhoff kill children and have no disease-modifying treatment. The science is not the bottleneck here — manufacturing a viral vector to regulatory standard is.
A 33% higher risk of major kidney events among patients on one blood-pressure drug class. The authors say plainly it cannot show the drugs caused it — and explain why the comparison is difficult.
Clinicians avoid steroids in infection because suppressing inflammation is assumed to suppress defence. In infected human macrophages, dexamethasone separated the two.
Twice rejected, then approved on a 24% response rate. What changed was not the data but the standard applied to patients with nothing left.
One lot of an intravenous arthritis biosimilar, recalled to user level after an internal investigation found glass particles in the vials.
Two things people can actually change, measured in midlife, tracked against cognition years later. The association is real; the causal claim is not established.
Antibodies against Staph, RSV and a common respirovirus predicted how well people responded to COVID vaccination — not because they fight COVID, but because they reveal the immune system’s general capacity.
Being invited to screen was linked to 26% lower death risk. Actually doing the test was linked to 43%. A third of people never sent a sample back.