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Same molecule, different delivery. Coffee gives 9–21 mg per ounce; an energy shot gives 40–69 — and concentration is the whole argument.
Genetics said Lp(a) causes heart disease. Pelacarsen lowered it convincingly in 8,300 patients. Cardiovascular events did not move — and the field now has to work out which part of that chain was wrong.
Pulmonary hypertension from left heart disease is common, dangerous and has no approved drug therapy. A catheter that burns nerves in the pulmonary artery halved clinical worsening — in an unblinded trial.
Takotsubo looks exactly like a heart attack until a catheter shows clear arteries. A blood-based score claims to separate the two at presentation — which is useful only if it never misses a real infarction.
Earlier tricuspid repair trials showed patients felt better and nothing more. TRIC-I-HF cut death and heart-failure hospitalisation by 60% — the first hard-endpoint win for the forgotten valve.
A 30% cut in cardiovascular events in healthy over-70s — and no difference in disability-free survival. Both findings are the trial’s result, and older adults may care more about the second.
A foxglove extract used since the eighteenth century, at less than 10 cents a day, cut heart-failure hospitalisations by about a quarter in a modern randomised trial.